Klami's output includes works for orchestra and soloists and orchestra, a chamber opera, chamber music, works for solo instruments, choral works, electro-acoustic works, multimedia works and electronic music for short films. In recent years Klami's music has been performed at many important music festivals and concerts in Finland and abroad in Nordic countries, around Europe, United States, Russia, South America and China.
Klami has received two First Prizes in national composition competitions in Finland with his orchestral works. In 2009, his Clarinet Concerto FUME was selected to the Jury's list of recommended works in the 2nd International Uuno Klami Composition Competition.
Klami has received commissions from and collaborated (among others) with clarinetist Lauri Sallinen, flutist Hanna Kinnunen, guitarists Patrik Kleemola, Timo Korhonen, Shin-ichi Fukuda, Thomas Müller-Pering, Fabio de Oliveira, Petrit Çeku, Massimo Felici, Kimmo Rahunen and Patrick Vena, bandonéonist Henrik Sandås, video artist Arttu Merimaa, Uusinta Chamber Ensemble, Turku 2011 European Capital of Culture, Se ensemble, The Polytech Choir, Chorus Cathedralis Iuniorum and Helsinki Guitar Duo.
In 2008-2011 Klami was the chairman of Ears Open Society, a society for young composers from and living in Finland. Ears Open promotes the works by youngest generation of composers by arranging public concerts, performances and seminars. In 2010 Klami was elected to the of board of Finnish Music Council where he represents the Society of Finnish Composers. Klami was one of the organizers of the international Brinkhall Summer Concerts Festival in Turku, Finland in 2008-2011. With Patrik Kleemola, Klami is founding member of MuSpark Society. The society arranges concerts of modern art music and aims to create bondings and co-operation between composers and performers on international level.